Technician Process Development 

Purpose of the role

The purpose of the role is to contribute in upstream process (USP) and downstream process (DSP) characterization; production of non-clinical material; and implementation of novel bioprocess technologies.

Place in the Organization

The Process Development (PD) department at Amsterdam is responsible for process development towards Phase I/II clinical testing. In addition, the department supports the Lexington PD in process development for Phase Ill and MAA, with scaling-up, process characterization and process validation. Both PD departments support the various stages of process development from research to GMP manufacturing.

The technician will work within a team of PD technicians and scientists where he/she is responsible for planning, performing and documenting USP and DSP for research and development purposes.

Key responsibilities

• Performs small to large scale USP and DSP of AAV.
• Properly collects, manages, analyzes and documents experimental data.
• Communicates the work and results to the direct supervisor and in group meetings
• Responsibility for laboratory, safety and equipment maintenance.
• Plans and executes experimental work in connection with time-lines.
• Strengthens the team in daily operations and troubleshooting DSP.

Qualifications & Skills

• BSc., Ms. or MLO education in life sciences or equivalent.
• Work experience in a comparable position is preferred.
• Practical experience with cell culture and USP. Preferably experience in working with bioreactors
• Practical experience with protein or virus purification: filtration, chromatography (FPLC, preferably experience with GE Äkta platform).
• Experience or willing to with working with GMO’s at ML-2 level.
• Experience in planning and organization.
• Basic understanding of molecular biology and virology
• Good verbal and written English communication skills.

Core competences

• High level of ownership, energy, hands-on mentality and personal drive
• Team player and attitude to motivate teams
• Good communication capabilities (effectively describing and conveying complex issues through reporting and presentations)
• Flexibility, to act in a fast changing and demanding environment
• Analytical thinking