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  • Location

    Amsterdam, Gemeente Amsterdam, North Holland

  • Job title:

    Histologist

  • Sector:

  • Job type:

    Permanent

  • Job ref:

    46661

  • Start Date:

    2021-08-26

The Company
This organization focuses on gene therapy to treat immunological diseases (ex. Huntington Disease, Parkinson's Disease, Haemophilia) using AAV-based vectors. This organization has several products in their pipeline at different stages of development and clinical trials phases, showing very promising results. 


Role Description 
As a Histologist you will support preclinical research projects by providing sample preparation, staining, and microscopy and imaging analysis.

Responsibilities 
- Troubleshoot protocols for histological staining, performance of equipment, and improves histology workflows;
- Carry out the preparations of frozen and FFPE specimens including embedding, section cutting, routine staining;
- Perform chromogenic and fluorescent IHC, ISH, and combination IHC & ISH;
- Monitor tissue and staining quality in slides;
- Operate an autostainer and a whole slide scanner;
- Prepare documentation and reports.


Requirements 
- BSc or MSc in Life Sciences or Biotechnology 
- Understanding of gene therapy read outs 
- Hands-on experience with sample preparation (cells, organs), sample fixation and prof level in sectioning with particular expertise in neuroanatomy;
- Hands-on experience with an autostainer (Leica Bond);
- Hands-on experience with a chromogenic and fluorescent IHC, ISH, combination IHC and ISH, and its troubleshooting;
- Hands-on experience with multiplex IHC (5 markers in one slide);
- Familiar with laboratory information management system is a plus;
- Experience with whole-slide imaging (Zeiss AxioScanner) is a plus;
- Experience with image analysis software (HALO, QuPath) is a plus. 


Other Information 
For more information please contact Carla Garcia at c.garcia@sire-search.com or +31 (0) 20 658 98 01. 

Contact us

SIRE® LIFE SCIENCES B.V.

Staten Bolwerk 1
2011 MK Haarlem
The Netherlands
+31 (0) 20 658 9800

SIRE® STAFFING SOLUTIONS B.V.

Keizersgracht 440A
1016 GD Amsterdam
The Netherlands
+31 (0) 20 658 9804